Dna Replication
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- Genetics: An IntroductionDNA: The Genetic MaterialDNA ReplicationGene FunctionGene Expression: TranscriptionGene Expression: TranslationDna Mutation,DNA Repair,and Transposable ElementsGenomics: The Mapping and Sequencing of GenomesFunctional and Comparative GenomicsRecombinant DNA TechnologyMendelian GeneticsChromosomal Basis of InheritanceExtensions of and Deviations From Mendelian Genetic PrinciplesGenetic Mapping in EukaryotesGenetics of Bacteria and BacteriophagesVariations in Chromosome Structure and NumberRegulation of Gene Expression in Bacteria and BacteriophagesRegulation of Gene Expression in EukaryotesGenetic Analysis of DevelopmentGenetics of CancerPopulation GeneticsQuantitative GeneticsMolecular Evolution
Question 1
Free
Short Answer
Please select the best match for each term.
A)A complex of helicase and primase on the template DNA
B)A DNA sequence that contains the specific region where replication begins
C)The distance between the origin and the termination of replication where two replication forks fuse
D)A complex of proteins and RNA that replicates the ends of eukaryotic chromosomes
E)A complex of key replication proteins at the replication fork in E.coli and bacteriophage DNA
-1)Primosome
2)Replicon
3)Replisome
4)Telomerase
5)Replicator
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Question 2
Free
Multiple Choice
During replication,the direction of synthesis of new DNA from the leading and lagging strands is
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5' to 3' only.
3' to 5' only.
from left to right only.
both 5' to 3' and 3' to 5'.
different,depending on whether the cell is prokaryotic or eukaryotic.
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Question 3
Free
Multiple Choice
DNA replication is always
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discontinuous.
bidirectional.
conservative.
semiconservative.
dispersive.
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Question 4
Free
Multiple Choice
In E.coli,replication begins at which chromosome site?
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The replication fork
ter
oriC
TBP
All of these
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Question 5
Free
Multiple Choice
Which of the following did Kornberg use to detect DNA synthesis?
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Radioactively labeled E.coli cells
Fluorescently labeled E.coli cells
Radioactively labeled deoxynucleotide triphosphates
Fluorescently labeled deoxynucleotide triphosphates
Nonlabeled deoxynucleotide triphosphates
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Question 6
Multiple Choice
How many replication forks are produced when DNA denatures at an origin?
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0
1
2
3
The number varies
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Question 7
Multiple Choice
What is a replication bubble?
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A complex of replication enzymes on the DNA template strand
A DNA sequence that initiates replication
A tangle of denatured DNA strands near the replication fork
A locally denatured segment of DNA where replication originates
A localized site in the nucleus where chromosomes are replicating
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Question 8
Multiple Choice
Which of the following are necessary for DNA replication in vitro?
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RNA,helicase,primers,DNA polymerase
Okazaki fragments,helicase,DNA polymerase
Template DNA,DNA polymerase,four dNTPs,primers,magnesium ions
Template DNA,four dNTPs,magnesium ions
DNA can't replicate in vitro
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Question 9
Multiple Choice
In Meselson and Stahl's experiment,what kind of DNA molecules would be found after four replication cycles?
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Only heavy DNA (15N-15N)
Only intermediate DNA (15N-14N)
Only light DNA (14N-14N)
Both heavy (15N-15N)and light DNA (14N-14N)
Both heavy (15N-15N)and intermediate DNA (15N-14N)
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Question 10
Multiple Choice
The two most basic steps of DNA replication are
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primase causes primer to bind the template and ligase copies the template.
helicase unwinds the template and DNA polymerase binds the template.
leading strand is copied first and lagging strand is copied second.
the new strand is denatured and a template is synthesized.
the template is denatured and a new strand is synthesized.
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Question 11
Multiple Choice
Where does the initiator protein bind DNA at the start of replication?
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At a replication fork
At an origin of replication
At any AT-rich region
At a promoter region
At a start codon
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Question 12
Multiple Choice
As helicase unwinds the DNA molecule,what keeps the strands apart?
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DNA polymerase
Reverse transcriptase
Replication fork
Single-strand binding proteins
Okazaki fragments
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Question 13
Multiple Choice
After removal of the RNA primers and replacement with DNA nucleotides,the single-stranded nick adjacent to Okazaki fragments is filled in through a reaction that involves which enzyme?
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DNA primase
SSB protein
RNA polymerase
DNA ligase
DNA helicase
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Question 14
Multiple Choice
Which enzyme elongates the new DNA strand starting at an RNA primer?
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DNA polymerase I
DNA polymerase III
RNA primase
DNA ligase
RNA polymerase
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Question 15
Multiple Choice
After a region of DNA has been replicated, ________ removes the RNA primers.
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DNA polymerase I
DNA polymerase III
DNA helicase
RNA primase
DNA ligase
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Question 16
Multiple Choice
Which enzyme replaces RNA primers with DNA after elongation?
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DNA polymerase I
DNA polymerase III
RNA polymerase
RNA primase
DNA ligase
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Question 17
Multiple Choice
Which kind of enzyme prevents DNA from tangling up by introducing negative supercoils as the replication fork migrates during replication?
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Helicase
Ligase
DNA polymerase I
DNA polymerase III
Topoisomerase
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Question 18
Multiple Choice
The base-pairing error rate remains low during replication because
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DNA repair mechanisms can fix the mispaired bases.
bases that are mispaired can excise themselves.
UV light radiation corrects any base mispairs.
mispaired bases cause a cell to die before replication is complete.
None of these; base-pairing errors are not possible
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Question 19
Multiple Choice
The enzymatic activity of a telomerase is best described as a
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polymerase.
ligase.
topoisomerase.
reverse transcriptase.
exonuclease.
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Question 20
Multiple Choice
Rolling circle replication of DNA is characterized by the absence of
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the DNA polymerase.
a nick in the DNA template.
the RNA primers.
the replication bubble.
the Okazaki fragments.
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