Functional And Comparative Genomics

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Question 1

Free

Short Answer

Please select the best match for each term.
A)Artificially introduced DNA
B)Fluorescent dye
C)Searches for sequence matches
D)Transcript that has a stem and loop
E)Small noncoding human RNA
-1)Transgene
2)shRNA
3)Cy5
4)HAR-1
5)BLAST

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Question 2

Free

Multiple Choice

Which of the following statements correctly describes reverse genetics?

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A mutated phenotype in an organism leads to the associated gene.

A mutated gene is introduced into an organism to determine the phenotype.

A gene is studied to understand the protein it encodes.

A transcript is used to make a protein encoded by a gene.

A gene is identified by bioinformatics.

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Question 3

Free

Multiple Choice

The subfield of genomics that deals with gene expression and interaction is

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comparative genomics.

functional genomics.

structural genomics.

hypothetical genomics.

expression genomics.

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Question 4

Free

Multiple Choice

The polymerase chain reaction has revolutionized genetics because

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it is capable of making virtually unlimited copies of DNA for study.

it is capable of making copies of DNA with very little starting material.

it is capable of making large numbers of DNA copies very quickly.

All of these

A and B only

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Question 5

Free

Multiple Choice

RNA interference functions by

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degrading the protein encoded by a specific mRNA.

degrading the RNA strand that is encoded by the Slicer gene.

transcribing double-stranded RNA into protein.

disrupting the chromosomal copy of the gene.

degrading the RNA complementary to the short,double-stranded RNA.

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Question 6

Multiple Choice

Which of the following triggers the RNAi pathway?

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mRNA

rRNA

tRNA

shRNA

snRNA

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Question 7

Multiple Choice

Which of the following is not used in PCR amplification of DNA?

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Double-stranded DNA template

Oligonucleotide primers

DNA polymerase

Buffer

ddNTPs

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Question 8

Multiple Choice

Which of the following does not occur during PCR?

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Denaturation at high temperatures

Synthesis of oligonucleotide primers

Annealing of oligonucleotide primers

Extension of primers by DNA polymerase

Changes in the reaction temperature by a thermocycler

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Question 9

Multiple Choice

If you are setting up a PCR reaction,how much extension time per cycle should you allocate for the Taq DNA polymerase to amplify a 5-kb DNA fragment from a 10-kb template?

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1 minute

2.5 minutes

5 minutes

10 minutes

20 minutes

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Question 10

Multiple Choice

The drug ________ is added to mouse cell cultures to select against transformants that do not have the desired gene knockout.

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ampicillin

kanamycin

neomycin

G418

ganciclovir

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Question 11

Multiple Choice

The Alu family is an example of

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short interspersed repeat elements.

intermediate repeat elements.

long interspersed repeat elements.

terminal sequences.

gene-flanking sequences.

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Question 12

Multiple Choice

A transgene is a

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hybrid gene.

gene that contains no introns.

bacterial gene that is found in mammalian cells.

human gene of viral origin.

gene introduced into an organism by artificial means.

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Question 13

Multiple Choice

The ________ gene is responsible for removing many of the drugs introduced into the human body.

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HAR-1

CYP2D6

ASPM

FOXP2

BRCA1

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Question 14

Multiple Choice

Which of the following is an archaean that has been identified in the human gut?

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Escherichia coli

Enterobacter aerogenes

Bifidobacterium longum

Methanobrevibacter smithii

Caenorhabditis elegans

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Question 15

Multiple Choice

Pharmacogenomics is the study of how

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the genome affects responses to drugs.

the genome leads to new drug discoveries.

the genome affects microbial communities in the body.

the genome is affected by drug use.

medicines influence the genome of cancer cells.

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Question 16

Multiple Choice

The human-accelerated region 1 (HAR-1)gene

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was identified by functional genomics.

is identical to the chimpanzee HAR-1.

encodes for the human accelerated region-1 protein.

is a small,noncoding RNA expressed in the brain.

is a small,regulatory RNA that regulates gene expression.

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Question 17

Multiple Choice

Linkage disequilibrium refers to a condition in which

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a set of SNPs recombine often.

a set of haplotypes recombine often.

a set of specific alleles of two or more genes tend to appear together.

a set of specific alleles of two or more genes only rarely appear together.

a haplotype block rearranges every generation.

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Question 18

Multiple Choice

A genomic region can rapidly become very common in a population due to

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positive selection.

negative selection.

specific selection.

linkage equilibrium.

homologous recombination.

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Question 19

Multiple Choice

The representational oligonucleotide microarray analysis (ROMA)represents

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a functional genomics approach.

a structural genomics approach.

a comparative genomics approach.

a metagenomics approach.

a pharmacogenomics approach.

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Question 20

Multiple Choice

Metagenomic analysis involves

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culturing microbes isolated from the environment.

extracting DNA from cultured microbes.

analyzing DNA from environmental samples.

sequencing cloned DNA individually.

determining culture conditions for different microbes.

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Functional And Comparative Genomics

Please select the best match for each term.A)Artificially introduced DNAB)Fluorescent dyeC)Searches for sequence matchesD)Transcript that has a stem and loopE)Small noncoding human RNA-1)Transgene2)shRNA3)Cy54)HAR-15)BLAST

Which of the following statements correctly describes reverse genetics?

The subfield of genomics that deals with gene expression and interaction is

The polymerase chain reaction has revolutionized genetics because

RNA interference functions by

Which of the following triggers the RNAi pathway?

Which of the following is not used in PCR amplification of DNA?

Which of the following does not occur during PCR?

If you are setting up a PCR reaction,how much extension time per cycle should you allocate for the Taq DNA polymerase to amplify a 5-kb DNA fragment from a 10-kb template?

The drug ________ is added to mouse cell cultures to select against transformants that do not have the desired gene knockout.

The Alu family is an example of

A transgene is a

The ________ gene is responsible for removing many of the drugs introduced into the human body.

Which of the following is an archaean that has been identified in the human gut?

Pharmacogenomics is the study of how

The human-accelerated region 1 (HAR-1)gene

Linkage disequilibrium refers to a condition in which

A genomic region can rapidly become very common in a population due to

The representational oligonucleotide microarray analysis (ROMA)represents

Metagenomic analysis involves

Please select the best match for each term.
A)Artificially introduced DNA
B)Fluorescent dye
C)Searches for sequence matches
D)Transcript that has a stem and loop
E)Small noncoding human RNA
-1)Transgene
2)shRNA
3)Cy5
4)HAR-1
5)BLAST